There are several options to get to Colonia del Sacramento from different parts of Uruguay:
By car: If you are traveling from Montevideo, you should take Route 1 to the west and then take Route 22 towards Colonia del Sacramento. The journey takes approximately 2 and a half hours. There are also options to rent a car in Colonia del Sacramento or in Montevideo.
By bus: There are several bus companies that offer regular services from Montevideo and other major cities in Uruguay to Colonia del Sacramento. The bus ride from Montevideo takes around 2 hours.
By ferry: Colonia del Sacramento has a port from where ferries depart that connect with Buenos Aires, Argentina. There are daily high-speed ferry services and the journey takes around 1 hour.
By plane: If you prefer to arrive by plane, the closest airport to Colonia del Sacramento is the Carrasco International Airport in Montevideo. From there, you can take a car or a bus to get to Colonia del Sacramento.