From Montevideo can be reached by taking Route 5 to Rivera, cross the border to Santana do Livramento (kilometer 495) and there follow the BR-293 to Quaraí, again crossing the border into Artigas.
Alternatively, take Route 30 at Kilometer 457 of Route 5, which reaches Artigas after about 130 kilometers.
Route 30 also connects with the west coast Artigas, through the junction with Route 3.